Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect
نویسندگان
چکیده
This review discusses two distinct, yet related, mechanisms of sodium-glucose cotransporter 2 (SGLT2) inhibition: Calorie restriction mimicry (CRM) and pro-ketogenic effect, which may explain their cardiovascular benefits. We term these adaptive CRM and pro-ketogenic effects of SGLT2 inhibition, the Robin Hood hypothesis. In English history, Robin Hood was a "good person," who stole from the rich and helped the poor. He supported redistribution of resources as he deemed fit for the common good. In a similar fashion, SGLT2 inhibition provides respite to the overloaded glucose metabolism while utilizing lipid stores for energy production.
منابع مشابه
Renal Sodium - Glucose Cotransporter Inhibition in the Management of Type 2 Diabetes 2 Mellitus 3
Revised 8-19-2015 (LOA) 1 Renal Sodium-Glucose Cotransporter Inhibition in the Management of Type 2 Diabetes 2 Mellitus 3 Muhammad A Abdul-Ghani, MD, PhD, Luke Norton, Ph.D., and Ralph A DeFronzo, MD 4 Division of Diabetes, University of Texas Health Science Center at San Antonio, Texas, USA 5 6
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